The Lemur Center's colony of Coquerel's sifaka is the most successful breeding colony in the world of this species or any species of sifaka. The Center maintains 21 animals (12 males, 9 females). The Lemur Center has been successful enough with our breeding program to send animals to other zoological institutions. The Los Angeles Zoo has a breeding group of four animals (an adult pair and their offspring), the Philadelphia Zoo has a sibling pair, and the St. Louis Zoo has a breeding group. The Paris Zoo has the only other established breeding group of sifakas in the world.
Coqerel's sifaka might be the most threatened of the verreauxi subspecies because of habitat destruction. It is found only in the Ankarafantsika Nature Reserve and the Bora Special Reserve, and these have both been damaged by yearly fires set by nearby farmers. Hunting of these animals by locals might occur in some areas, although in many parts of its range it is protected by taboo or fady.